Cancer-fighting immunosuppressive agents shown to disrupt telomeres and suspend growth of cancer cells CHICAGO , Aug. 13, ...

Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.

Structure and function of telomeric regions The structure of telomeric regions is generally conserved among organisms from yeasts to humans with some exceptions, including flies (see below).

A class of DNA folds/structures known collectively as G-quadruplexes (G4) commonly forms in guanine-rich areas of genomes. G4-DNA is thought to have a functional role in the regulation of gene ...

G-quadruplex structures can be formed at the single-stranded overhang of telomeric DNA, and ligands able to stabilize this structure have recently been identified as potential anticancer drugs. Among ...

A research team from National Taiwan University, Academia Sinica, and National Taiwan University Hospital has uncovered a critical connection between a unique RNA molecule and human aging ...