Fragile X disorders include two distinct conditions: fragile X syndrome (the most common single-gene cause of developmental delay and autism) and an entirely separate group of premutation syndromes.

Explore this issue of The New England Journal of Medicine (Vol. 0 No. 0).

The author describes the scientific foundations and implications of a study on variant EPO and erythrocytosis.

A 61-year-old man presented with hypoxemic respiratory failure and shock 10 weeks after kidney transplantation. A purpuric rash was present on the abdomen. A diagnosis was made.

Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular reocclusion may occur after intravenous thrombolysis and may be preventable wi ...

The landscape for genetically modified organisms is changing, thanks to sharp increases in the amounts and numbers of chemical herbicides applied to GM crops and the classification of two of the mo ...

Primary care physicians have been leaving traditional practices for concierge and direct primary care practices, in which patients are offered personalized and more accessible primary care in excha ...

New AI-based software for generating patient notes purposely filters out social “chitchat,” but a primary care physician sees serious risks in that practice, for doctors and patients alike.

Explore Interactive Medical Case articles from The New England Journal of Medicine ...

The exclusively human pathogen Neisseria meningitidis, which was first described in 1805 after an outbreak of 33 cases in Geneva, Switzerland, has been feared worldwide for more than 215 years as a ...

Traumatic acute subdural hematomas often warrant emergency evacuation of the blood clot to avoid further cerebral compression and its sequelae. Once the subdural clot is removed, the million-dollar ...

The slow speed of science contributes to public concern about vaccines and reduced immunization coverage. Postauthorization safety research requires timely funding linked to the introduction of ...