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The EMBO Journal
6 小时
Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ ...
To address the unmet need for a cure for RTT, the therapeutic potential of adult Neural Precursor Cells (NPCs) was ...
The EMBO Journal
1 天
Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...
The EMBO Journal
1 天
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Mice express full-length protein ZBP1-L as well as an alternatively-spliced shorter isoform (ZBP1-S) containing only its two ...
The EMBO Journal
2 天
Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis
Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...
The EMBO Journal
3 天
Goliath, meet David
K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.
The EMBO Journal
4 天
Tissue-aware interpretation of genetic variants advances the etiology of rare diseases
A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...
The EMBO Journal
4 天
RNA fine-tunes estrogen receptor-alpha binding on low-affinity DNA motifs for ...
RNA modulates transcription factor binding to DNA, though the subsequent effect on transcription remains unclear. The study ...
The EMBO Journal
4 天
RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation
MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...
The EMBO Journal
4 天
Metabolism: getting things right!
It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...
The EMBO Journal
4 天
IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis ...
How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...
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