Immunotherapy can remove extracellular amyloid plaques from Alzheimer’s brain, but has so far failed to clear intracellular tau tangles. Now, two papers propose a solution: tagging them for ...

Alzheimer’s is a multifaceted disease, particularly in its sporadic, late-onset form. Myriad factors—genetics, environment, ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Synonyms: TAR DNA-binding protein 43, TDP43, TARDBP, ALS10, transactive response DNA-binding protein of 43 kDa ...

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PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

Lo and behold, he found a 317-bp AluYb8 retrotransposon lurking within the 3ˈUTR of people who carried the SNPs corresponding ...

Andreasson and colleagues have found, using both in vitro and in vivo models, that kynurenine (Kyn) generated by IDO1 ...

But some 80 percent of people with Parkinson's disease have GI problems, such as acid reflux, irritable bowel syndrome, and constipation, which often emerge decades before motor difficulties do. This ...

The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.

This brain bank stores frozen tissue. All donations go in through the lab's clinical core, and have been tested and diagnosed. The lab shares brain tissue through its biospecimen core.

When Alois Alzheimer described the case of Auguste D. to an audience of fellow psychiatrists in Tuebingen, Germany, in 1906, what set her case apart was the fact that her dementia appeared before she ...