PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

This widely used tauopathy model was developed at the University of Pennsylvania School of Medicine by Virginia Lee, John Trojanowski, and colleagues. As first reported in 2007 on a mixed background, ...

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Postdoctoral Position- Neurobiology of Parkinson’s Disease JOB 2025-07-09 Employer Université Laval Contact [email protected] Description The team specializes in the study of ...

A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.

Up-and-coming Alzheimer’s blood tests may soon be used for people with Down’s syndrome. In a longitudinal biomarker study of adults with three copies of ...

Research News Parkinsonian disorders are difficult to diagnose. Clinical symptoms often overlap ...

CagA disrupts bacterial biofilms. It also prevents Aβ and α-synuclein from forming fibrils. Scientists will test CagA in AD and PD mouse models to assess its therapeutic potential. Scientists estimate ...

To satisfy the incessant energy demands of their thousands of synapses, neurons have to have enormous supplies of ATP at the ready. Where does this seemingly bottomless well of energy come from? It’s ...