Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

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We report an asymmetric total synthesis of (−)-illisimonin A, a sesquiterpene natural product with neurotrophic activity. Illisimonin A possesses a unique cage-like 5/5/5/5/5 pentacyclic scaffold ...

Small thiolate-protected gold molecular clusters have gained significant interest in research due to their unique size-dependent properties. Their molecular to nanoscale sizes lead to distinctive ...

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Classical empirical force fields have dominated biomolecular simulations for over 50 years. Although widely used in drug discovery, crystal structure prediction, and biomolecular dynamics, they ...

The development of single-atom catalysts (SACs) with site-specific and tunable catalytic functionalities remains a highly desirable yet challenging goal in catalysis. In this study, we report a SAC ...

Extracellular vesicles (EVs) are a vital component in cell–cell communication and hold significant potential as biomarkers and therapeutic carriers. Having a reproducible and simple EV isolation ...

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Promoting the reactivity of surface lattice oxygen atoms of oxide nanomaterials is critical for enhancing their catalytic performances in oxidation, hydrogenation, and electrocatalytic reactions; ...

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Microplastics (MPs) serve as carriers for microbial community colonization, forming unique ecosystems known as plastispheres in urban aquatic ecosystems. However, interactions among microbes, ...