Gamma-secretase allosteric stabilizers (GSAS), in contrast to γ-secretase inhibitors (GSI), theoretically allow normal physiological processing of the many substrates of the γ-secretases, while ...

file to determine the optimal minimum run length for processive runs in your future analysis. This is decided by looking at the output plots when the alpha of diffusive runs is near 1, alpha of ...

The mode of subunit addition regulates the processive elongation of actin filaments by formin Journal: Journal of Biological Chemistry Published: 2024-12-10 DOI: 10.1016/j.jbc.2024.108071 ...

Development of sequential mixing, single turnover stopped-flow approach reveals processive protein unfolding catalyzed by Escherichia coli ClpB.

Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol ε ...

Molecular dynamics simulations revealed that the driving force of processive catalysis might be related to the changes in interaction energy. This study provided a rational design strategy targeting ...

Establishing a suitable immobilization strategy to improve the accessibility of immobilized cellulase for insoluble cellulose and subsequently recover the enzyme from the remaining substrate is ...

K.C. Chou, F.J. Kezdy, F. Reusser, Review Kinetics of processive nucleic acid polymerases and nucleases, Anal. Biochem., 221 (1994) 217-230.

Specialized polymerases differ as they are far less processive since their involvement in replicating damaged DNA requires that they only by-pass unrepaired DNA lesions that occur sporadically ...

(4) Less processive ATP-dependent proteases have a tendency to slip once they reach a more tightly folded domain, and if the ATP hydrolysis rates slow below a critical threshold they will stall and ...

The kinesin-14 motor Kar3 moves along microtubules using a previously undescribed mechanism that critically requires the presence of a non-catalytic head.

The collective behaviors of certain processive motors, like myosinVa, may therefore be more readily tunable and have more substantial roles in intracellular transport regulatory mechanisms compared ...