Summary: New research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using ...

Homeostatic plasticity, the brain's method of preserving equilibrium in neural circuits, relies heavily on spontaneous ...

It allows you to detect and analyse spontaneous postsynaptic potetnials/currents in whole-cell patch clamp recordings and to estimate the quantal size in the central synapse.

A protein that appears in postsynaptic protein agglomerations has been found to be crucial to their formation. The Kobe University discovery identifies a new key player for synaptic function and ...

imageimageNeuronal hyperactivity and elevated susceptibility to seizures have been observed in early stage of Alzheimer’s disease. Accumulation of Aβ leads to an elevation of excitatory synapse ...

Under typical monosynaptic rabies tracing conditions about 40% of first-order presynaptic synapses to cortical neurons are labeled and spread efficiency does not vary depending on the distance of ...

Action potential (AP)-triggered neurotransmitter release forms the key basis of inter-neuronal communication. We present a stochastic hybrid system model that captures the release of ...

Neuronal reactivation during dopamine modulation induces input-specific LTP at previously primed hippocampal synapses, suggesting a possible solution to the credit assignment problem and a mechanism ...

Neurotoxins can be divided into presynaptic neurotoxins and postsynaptic neurotoxins based on their mechanism of action. The two neurotoxins have important application in basic research and drug ...

Neuroligin-1 (Nlgn1) is a postsynaptic cell-adhesion protein exclusively localised to excitatory synapses that is crucial for coordinating the transsynaptic alignment of presynaptic release sites with ...