Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid molecules in the body. The inhibition of two of these lipid kinases, ...

Thus, p90RSK promotes survival and accumulation of macrophages, especially the M1 macrophages, through phosphorylating its intracellular p38 MAPK pathway. These increased M1 macrophages, in turn, ...

A crucial connection between transcriptional regulation and the cell cycle occurs via transcriptional cyclin-dependent kinases (CDKs), CDK12 and its paralog, CDK13, which regulate transcription by ...

Organophosphate (OP) compounds, such as paraoxon (POX), inhibit enzymes critical for neurotransmission, causing severe neurotoxic effects. Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM is ...

The rhizobial effector NopT and two Nod factor receptors of Lotus japonicus, NFR1 and NFR5, mutually interact to precisely regulate rhizobial symbiosis.

The concept of genetic code expansion (GCE) has revolutionized the field of chemical and synthetic biology, enabling the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins, ...

An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.

Moreover, by phosphorylating Beclin-1 at Ser90/93/96, PRKAA/AMPKα boosts the assembly of the Beclin-1-SLC7A11 complex, inhibits system xc−, and stimulates the resulting ferroptotic demise of cancer ...

MST4 led to the accumulation of 7-HOCA by phosphorylating ACLY, furthermore, 7-HOCA promoted endothelial cell injury. Targeting the MST4/ACLY pathway ameliorated cardiac microvascular I/R injury, ...