Nucleophilic substitution reactions remain a cornerstone of organic chemistry, offering a window into the fundamental aspects of reactivity and selectivity in molecular transformations.

The phase transfer nucleophilic substitution method was used to explore the removal of organochlorine compounds (OCs) from six chlorine-containing model oils and the kinetics of the dechlorination ...

Unsymmetrical ureas can form multiple stable hydrogen bonds with proteins. Since drugs containing urea functional groups display unique biological activities when interacting with their targets, they ...

One of the most important reactions of 1,2,3-triazines with a dienophile is inverse electron demand Diels–Alder (IEDDA) cycloaddition, which occurs through nucleophilic addition to the triazine ...

Semiemperical and density functional methods (DFT) have been used to predict the reactivity of some amino acids (leucine, aniline and glycine) towards electrophilic and nucleophilic attacks with iron ...

The nucleophilic addition of several nucleophiles (allyltrimethylsilane, silyl enol ether from acetophenone, indole and N-sulfonylindole) to the enantiopure cyclic N-acyliminium ion 1a, derived from ...

If nucleophilic attack is the first step, deprotonation of the primer 3′-OH by a general base would be essential to initiate the reaction (Fig. 1 A). In the more than three decades since the first DNA ...

In undergraduate organic chemistry courses, nucleophilic substitution reactions are often carried out as an experiment.

Article citations More>> B. M. Trost and G. R. Dake, “Nucleophilic α-Addition to Alkynoates. A Synthesis of Dehydroamino Acids,” Journal of the American Chemical Society, Vol. 119, No. 32, 1997, pp.