本研究针对肾脏疾病诊断与预后监测中传统生物标志物的局限性，创新性地探讨了神经丝轻链蛋白 (Neurofilament Light Chain, NfL)在慢性肾脏病 (CKD)、急性肾损伤 (AKI)和糖尿病肾病中的临床应用价值。通过系统分析PubMed、Embase等六大数据库的现有证据，研究团队发现血清NfL水平与肾功能指标 (eGFR、血清肌酐 ...

Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. Journal of Neurology, 2019; DOI: 10.1007/s00415-019-09567-8 ...

The blood-based measure of neurofilament light chain was associated with the presence of neuronal injury in those with peripheral neuropathy, according to a systematic review and meta-analysis in ...

The Company plans to hold an end-of-Phase 2 Type B meeting with the FDA in the third quarter of 2025. This meeting will review results from the Phase 2 VISIONARY-MS trial and discuss the planned Phase ...

Therefore, insults to α-internexin-neurofilament and any associated proteins would likely cause central nervous system degeneration (Cairns et al., 2004). Alterations to the peripherin-neurofilament ...

A paper published online today in Nature Medicine finds that in familial Alzheimer’s disease, blood levels of neurofilament light (NfL) rise 16 years before the predicted age of onset. Scientists led ...

CSF neurofilament may be one such surrogate marker," Avindra Nath, MD, professor of neurology at Johns Hopkins University, told Medscape Medical News.

Neurofilament light chain (NfL), which is released from axons upon injury or neuronal death, was measured using Quanterix Simoa assays, while T-tests were employed to compare overnight changes in ...

Blood-based measurement of neurofilament light chain (NfL) provides compelling evidence to support an accelerated drug approval by the FDA. The decision has positive implications for NfL blood ...

Nitz E, Smitka M, Schallner J, et al. Serum neurofilament light chain in pediatric spinal muscular atrophy patients and healthy children. Ann Clin Transl Neurol. Published online September 4, 2021 ...