Solubilizing agents are routinely added when investigating the biotransformation of lipophilic substrates using hepatic microsomes. For highly lipophilic compounds, the concentration of solvent or ...

Can microsomal triglyceride transfer protein (MTP) inhibitors provide an alternative way to lower LDL-cholesterol levels in patients who do not tolerate statins?

Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas disease. As recent studies have de-monstrated cardiotoxic effects of Nfx, we attempted to determine whether Bz behaves similarly.

Microsomal preparation was performed according published procedures (Marques et al., 2014). Rat liver microsome incubations (shaking water bath at 37 °C) were performed in 10 ml amber tubes in a total ...

The preparation of microsomal membrane proteins (MPs) is critically important to microsomal proteomics. To date most research studies have utilized an ultracentrifugation-based approach for the ...

By specifically targeting microsomal prostaglandin E synthase-1 (mPGES-1) activity with a small molecule inhibitor we could block CAF-derived PGE 2 production leading to reduced tumor growth, impaired ...

The hepatic microsomal enzyme system is a collection of enzymes present in the liver. It includes the Cytochrome P450 enzymes.

An antithyroid microsomal antibody test is also called a thyroid peroxidase test. It measures antithyroid microsomal antibodies in your blood.

Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme situated downstream of cyclo-oxygenase-2, promoting the excessive PGE 2 production in inflammation. Dexamethasone is known to ...