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蝎毒肽TsAP-2的体外体内抗菌活性及三维结构解析 ...
面对多重耐药菌引发的全球公共卫生危机,巴西研究团队从蝎毒中分离出抗菌肽TsAP-2,通过体外实验证实其对MRSA等革兰阳性菌的广谱抗菌和抗生物膜活性,体内实验显示其促进伤口愈合和幼虫存活。核磁共振解析的三维结构揭示其膜作用构象变化,为新型抗感染药物研发提供候选分子。
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