Objective—Our goal was to examine the influence of indirubin-3′-monoxime (I3MO), a natural product–derived cyclin-dependent kinase inhibitor, on vascular smooth muscle cell (VSMC) proliferation in ...

Conclusion: Indirubin, the primary bioactive metabolite of Isatidis Folium, exerts protective effects against sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages.

To enhance the ability of indirubin derivatives to inhibit CDK2/cyclin E, a target of anticancer agents, we designed and synthesized a new series of indirubin-3′-oxime derivatives with combined ...

Objective: To identify the key genes and potential signaling pathways of indirubin against Ulcerative colitis (UC). Methods: Two mRNA datasets (GSE37283 and GSE87466) were obtained from the Gene ...

Indirubin is an isomer of the blue dye indigo. It is widely used in Chinese medicine as part of therapy against many diseases and, thus, its skeleton becomes a promising candidate for new drug ...

Indirubin is an isomer of the blue dye indigo. It is widely used in Chinese medicine as part of therapy against many diseases and, thus, its skeleton becomes a promising candidate for new drug ...

Researchers from China Pharmaceutical University have reported the discovery and preclinical evaluation of novel bifunctional molecules inducing DNA damage and targeting PARP for the treatment of ...

By observing the therapeutic effect of indirubin combined with stem cells in the treatment of psoriasis-like skin lesions in BALB/C mice, this paper aims to elucidate the immune mechanism of indirubin ...

Our colleagues demonstrated that indirubin and its analogue Meisoindigo were effective agents in the treatment of chronic myeloid leukemia in preclinical and clinical trials. Indirubin-3′-monoxime ...