New synthetic biosensors developed by Professor Josh Leonard give immune cells the ability to read their environment and act ...

Results: Patients with early-stage liver cirrhosis exhibited significantly higher methylation levels of Ring finger protein 41 promoter than chronic hepatitis B patients and health controls, ...

BACKGROUND: HIMF (hypoxia-induced mitogenic factor) induces pulmonary hypertension; however, the molecular nature of its extracellular membrane receptor(s) remains unknown. METHODS: A combination of ...

The enzyme prefers to snip substrates with a short ectodomain, which is typically generated by shedding enzymes such as α- and β-secretase. Beyond these basic features, complex factors influence ...

In a complementary study, detailed examinations of TLR ectodomain architecture have demonstrated that the arrangement and integrity of leucine-rich repeats (LRRs) play a decisive role in ...

Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics ...

In fact, EGFR-Her2 ectodomain heterodimers have not yet been directly observed, following ligand binding, although there are hints from biophysical studies that weak Her2-Her3 ectdomain dimers may ...

Objective—CD36 phosphorylation on its extracellular domain inhibits binding of thrombospondin-1. The mechanisms of cellular CD36 ectodomain phosphorylation and whether it can be regulated in cells ar ...

The proton channels of influenza A virus (A/M2) and influenza B virus (BM2) are essential for viral replication. Previously we have shown that monoclonal antibodies targeting the ectodomain of the ...