About this article Cite this article Perlmutter, D. Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in α -1-antitrypsin deficiency.

Autophagic flux is determined by assessing the steady-state levels of autophagic substrates in the absence and presence of inhibitors of autophagosome–lysosome fusion or lysosomal degradation.

More information: Takuya Norizuki et al, Dynamic rearrangement and autophagic degradation of mitochondria during spermiogenesis in the liverwort Marchantia polymorpha, Cell Reports (2022).

Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly ...

Researchers have reported that in the liverwort Marchantia polymorpha, the number of mitochondria in the spermatozoid (sperm) is controlled by autophagy during spermiogenesis.

Dynamic rearrangement and autophagic degradation of the mitochondria during plant spermiogenesis Peer-Reviewed Publication National Institutes of Natural Sciences ...

They found that intact autophagic vacuoles are indispensable in mediating competitive elimination of cancer cells. Conversely, perturbation of autophagy prevents cell elimination, thereby ...