他们发现，用2-溴铝酸盐(2-BP)——一种蛋白质酰基转移酶抑制剂——处理衰老的人类血管平滑肌细胞(VSMCs)与衰老表型的不同方面的变化有关，包括细胞增殖的恢复，DNA损伤标记物的减少和衰老相关的β-半乳糖苷酶活性的下调。 假设抑制蛋白质棕榈酰化可以调节 ...

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science ...

For the first time, the present study revealed a critical role for protein palmitoylation in the development of a DNA ...

They showed that treatment of senescent human vascular smooth muscle cells (VSMCs) with 2-bromopalmitate (2-BP) - an ...

Atherosclerosis in the form of peripheral arterial disease results in significant morbidity and mortality. Surgical treatment options for peripheral arterial disease include angioplasty with and ...

5 Naringin inhibits the growth, proliferation, invasion, and migration of VSMCs, and induces cell cycle arrest at the G1 phase, demonstrating its potential utility in the prevention of AS Figure 4.

The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells. We assessed the ...

Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Spain (M.R.H., V.Q., C.L.-O.). Centro de ...

Background: Aortic dissection (AD) is a fatal cardiovascular disease for which the key involved genes are largely unknown. Here, we aimed to identify promising AD biomarkers from high-throughput RNA ...

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of ...

A recent study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and ...