研究发现PCNA的立体约束迫使Polε解旋6个碱基对（远超既往报告的3bp），形成独特的'错位碱基配对'结构，揭示了滑动钳（sliding clamp）在维持复制保真度中的核心作用，为癌症相关POLE1突变导致的C-to-G颠换（transversion）提供了分子解释。

In the current study, allele specific expression analysis was performed in two subspecies cows (Bos taurus and Bos indicus) at SNP and gene levels. RNA-Seq data of 21,078,477 and 20940063 paired end ...

Methylation, a widely occurring natural modification serving diverse regulatory and structural functions, is carried out by a myriad of S-adenosyl-l-methionine (AdoMet)-dependent methyltransferases ...

e20089Background: Lung adenocarcinoma in young adults (≤50) has an aggressive course even in the presence of targetable mutations. Prior US studies were conducted predominantly in the Northeast where ...

The A:8OG base pair (bp) is the outcome of DNA replication of the mismatched C:8OG bp. A high A:8OG bp population increases the C/G to A/T transversion mutation, which is responsible for various ...

By coupling mOsMPG with a transactivation factor VP64, rAKBE04 could enable simultaneous A-to-G and A-to-T transition and transversion base editing in rice stable lines.

The G-to-U transversion of miR-483 alters the original mRNA targeting efficacy and allows 8 OH-G miR-483 to recognize new mRNA target sites. As such, miR-483 targets connective tissue growth factor ...

The co-circulation of BF.7 and BA.5.2 has been present in the current outbreak since Nov 14, 2022 in Beijing, and there is no evidence that novel variants emerged. Although our data were only from ...

The accumulation of somatic mutations during aging is not uniform across tissue types and, in addition, shows significant variability in the source of mutation that can be modified by small molecule ...

4566Background: Patients with advanced metastatic urothelial carcinoma (mUC) who experience disease progression after standard therapy have limited treatment options. Toripalimab was approved for the ...

Hence, prime editing, which has transversion mutations ability, should also be considered an efficient alternative to single base edits. Although base editing has great potential for the improvement ...