Methods: To test this hypothesis, eight weeks old hypertensive BPH/2J and normotensive BPN/3J female mice (n=6) were first characterized for their RBC physiology and subsequently infected with ...

编辑推荐： 本研究首次在加蓬入侵物种黑家鼠 (Rattus rattus)中检测到啮齿类疟原虫Plasmodium yoelii，通过系统筛查527只农村地区捕获的啮齿动物，发现2例阳性样本 (0.38%)。研究采用分子生物学技术结合系统发育分析，证实其与当地原生啮齿动物携带的虫株高度同源，挑战了"啮齿类疟原虫仅限原生宿主"的 ...

In order to study the kinetics and composition of the polyclonal B-cell activation associated to malaria infection, antigen-specific and non-specific B-cell responses were evaluated in the spleens of ...

We further show that Olfr1386 regulates type I interferon (IFN-I) responses, and deletion of the Olfr1386 reduces IFN-α/β levels after Plasmodium yoelii YM infection. Additionally, we identify ...

[The number of TIGIT+CD8+ T cells increases but their cytokine secretion decreases in the lungs of Plasmodium yoelii infected mice]. August 01, 2023 [ MEDLINE Abstract ] « Previous Next » ...

Our results indicate that DCs remain competent to activate T cells during Plasmodium infection, but that T cell polarization and humoral responses are severely disrupted. This study provides ...

To elucidate the mechanisms underlying host–parasite interaction, we performed a genetic screen during early (24 h) Plasmodium yoelii infection in mice and identified a large number of interacting ...

Novel 6-arylethyl-1,2,4-trioxanes6a–i and 7a–i are easily accessible in one step from the diimide reduction of 6-arylvinyl-1,2,4-trioxanes 5a–i. All of these new trioxanes were assessed for their oral ...

image image The mechanisms controlling the gender‐specific transcription programs of gametocytes of malaria parasites are largely unknown. This study identifies a transcription repressor factor AP2‐O3 ...

Mice were infected with Plasmodium yoelii and administered metformin. Levels of parasitemia were reduced in treated mice compared with those in untreated mice, starting at ~2 weeks post-infection.