Long noncoding RNAs (lncRNAs) could be a byproduct of transcription (i), a scaffold linking proteins (ii) or a guide bringing proteins to specified parts of the genome (iii).

This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger ...

Review Article Published: 08 November 2012 Interpreting noncoding genetic variation in complex traits and human disease Lucas D Ward & Manolis Kellis Nature Biotechnology 30, 1095–1106 (2012 ...

Campus News New blood test for noncoding RNA significantly improves cancer detection Assistant Professor of Biomolecular Engineering Daniel Kim and his lab are developing more accurate and powerful ...

"These noncoding RNAs may yield new biomarkers and therapeutic targets for cancer treatment, a potential opportunity for personalized medicine given their cell type-specific expression," added ...

New research shows modifying noncoding RNA with N6-methyladenosine allows the RNA exosome to recognize a specific noncoding RNA associated with the genomic site that encodes the heavy chain of ...

To identify noncoding mutations that are associated with functional effects in cancer, Dr. Ideker’s team turned back to TCGA data and carried out a systematic analysis of 930 tumors, integrating ...

Yet other noncoding RNAs have been linked to sundry neurological conditions, including learning disorder s and autism spectrum disorder. Most lack mechanistic explanations for their contributions to ...

What is noncoding DNA, and why do we need it? In 1953, James Watson and Francis Crick built a 3-D cardboard cutout model of a DNA molecule shaped like a double helix, and in so doing, divined the ...

Noncoding mutations contribute to autism risk Date: December 14, 2018 Source: Simons Foundation Summary: A whole-genome sequencing study of nearly 2,000 families has implicated mutations in ...

Noncoding RNAs (ncRNAs) are defined as RNAs that do not contain any open reading frames greater than 300 nucleotides (enough to code for 100 amino acids). Researchers once assumed “that proteins ...

Noncoding mutations in children with autism have greater impact scores, on average, than those in their unaffected siblings, the researchers found.