This AI system can analyze up to one million DNA letters at once, predicting how tiny changes in noncoding regions trigger everything from cancer to rare genetic disorders—and potentially revolutioniz ...

Immunotherapy employs patients' own immune systems to fight cancer, and it has shown itself to be an effective treatment in ...

To identify noncoding mutations that are associated with functional effects in cancer, Dr. Ideker’s team turned back to TCGA data and carried out a systematic analysis of 930 tumors, integrating ...

Campus News New blood test for noncoding RNA significantly improves cancer detection Assistant Professor of Biomolecular Engineering Daniel Kim and his lab are developing more accurate and powerful ...

"These noncoding RNAs may yield new biomarkers and therapeutic targets for cancer treatment, a potential opportunity for personalized medicine given their cell type-specific expression," added ...

New research shows modifying noncoding RNA with N6-methyladenosine allows the RNA exosome to recognize a specific noncoding RNA associated with the genomic site that encodes the heavy chain of ...

The paper D.M. Anderson et al., “A micropeptide encoded by a putative long noncoding RNA regulates muscle performance,” Cell, 160:595-606, 2015. The transcript Eric Olson and his colleagues at the ...

Noncoding mutations contribute to autism risk Date: December 14, 2018 Source: Simons Foundation Summary: A whole-genome sequencing study of nearly 2,000 families has implicated mutations in ...

Review Article Published: 08 November 2012 Interpreting noncoding genetic variation in complex traits and human disease Lucas D Ward & Manolis Kellis Nature Biotechnology 30, 1095–1106 (2012 ...

Yet other noncoding RNAs have been linked to sundry neurological conditions, including learning disorder s and autism spectrum disorder. Most lack mechanistic explanations for their contributions to ...

Clinical Implications of Basic Research A Notch for Noncoding RNA in Melanoma Author: Levi A. Garraway, M.D., Ph.D. Author Info & Affiliations Published May 15, 2014 N Engl J Med 2014;370: 1950 - 1951 ...

Long noncoding RNAs (lncRNAs) could be a byproduct of transcription (i), a scaffold linking proteins (ii) or a guide bringing proteins to specified parts of the genome (iii).