JB3（序列：D-CSKAPKLPAAYC）是一种具有高特异性、稳定性强的D-构型环状多肽，可靶向结合IGF-IR，用于肿瘤的靶向诊断与治疗。 GGYTFHWHRLNP DTBP-3 PVR的抗酶降解D肽阻… ...

DSPE-PEG-JB3（D-CSKAPKLPAAYC）是一种由脂溶性锚定基团DSPE、亲水性PEG链和靶向IGF-IR的JB3多肽构成的功能化分子，用于实现对IGF-IR阳性肿瘤的精准识别与递送。 DSPE 是一种长链磷脂，能够牢固嵌入脂质体或纳米颗粒的脂双层中，作为 ...

The type 1 insulin-like growth factor I (IGF-IR) receptor plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.

More information: Denian Wang et al, Adrenomedullin 2 attenuates anxiety-like behaviors by increasing IGF-II in amygdala and re-establishing blood–brain barrier, Translational Psychiatry (2025).

IGF-II通过IGF-IIR发挥神经保护 杏仁核注射IGF-II可使焦虑行为改善率达75%，但IGF-IR抑制剂JB1无阻断效应。 相反，IGF-IIR抗体完全逆转IGF-II疗效，并抑制AKT-mTOR通路激活，证实IGF-IIR是核心作用靶点。

Minghui Pharmaceutical Inc. Announces Positive Topline Results from Phase Ib/II Clinical Trial of MHB018A, a Subcutaneous Single-Domain IGF-1R Antibody, in Patients with Active, Moderate-to-Severe ...

Looking at the effect of PAPP-A inhibition on IGF-IR activation, the investigators found that cell proliferation, differentiation, and survival were mediated by IGF-I stimulation of the ...

In addition, We also respectively investigated insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) of blood serum of nude mice, IGF-ImRNA, insulin-like ...

In primary endothelial cells isolated from human IGF‐1 receptor endothelial overexpressing mice (hIGFREO) and wild‐type littermates (WT), quantitative polymerase chain reaction (qPCR) shows that ...

IGF-IR blocking drugs may also induce hyperglycemia and hyperinsulinemia, which may further stimulate cell growth. In addition, circulating IGF-IRs may reduce therapeutic effects of IGF-IR targeted ...

Therefore, IGF-IR might be an important potential therapeutic target in breast cancers resistant to trastuzumab. Targeting IGF-IR may be a rational approach to improve response to trastuzumab in the ...