Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

Developing oral biologics has long been a holy grail of protein engineering. Traditional antibodies are large and unstable in the presence of gastrointestinal proteases. Here, we present a strategy to ...

We compared the caecal microbiome of IL10KO WT and HOM birds at 4 weeks of age using 16S rDNA V3-V4 hypervariable amplicon sequencing as described (30, 31). The caecal microbiome of both genotypes was ...

Wahls, W.P., Wallace, L.J. and Moore, P.D. (1990) Hypervariable Minisatellite DNA Is a Hotspot for Homologous Recombination in Human Cells. Cell, 60, 95-103.

Then, the researchers scored how well the model could generate a representation for hypervariable regions of known antibody structures, testing its accuracy and training it to improve.

FMT alleviated the intestinal barrier damage caused by enterotoxigenic Escherichia coli infection in antibiotic-induced microbiome-disordered model through increasing the relative abundance of A.

Hypervariable regions vary in length but usually contain fewer than 40 amino acids. It has been estimated that the human immune system can produce up to 1 quintillion different antibodies by changing ...

Cell cross-contamination in cell cultures is a common problem during cell culturing and use. Contamination invalidates research results, compromises the comparison of results between laboratories, ...

Researchers developed AbMAP, a cutting-edge framework leveraging transfer learning to model antibody hypervariable regions, significantly improving design and immune repertoire analysis.

We provide evidence of a life–course relationship between gut microbiome profiles and metabolic health.

Yang, B., Wang, Y. and Qian, P. (2016) Sensitivity and Correlation of Hypervariable Regions in 16S rRNA Genes in Phylogenetic Analysis. BMC Bioinformatics, 17 ...

These results inform and support a programme of clinical evaluations of the HIVconsvX T-cell vaccines together with other cutting-edge tools for HIV-1 cure and prevention such as latency reactivating ...