编辑推荐： 本研究针对GSTM1和GSTT1基因缺失多态性与多发性骨髓瘤 (MM)发病风险的争议性问题，通过系统评价4项研究共1131例样本，首次证实GSTM1缺失可降低MM风险 (OR=0.66)，而GSTT1缺失显著增加风险 (OR=1.60)。该Meta分析为MM的遗传易感性机制提供了新证据，对高危人群筛查具有重要临床意义。

The deletion of GSTT1 and GSTM1 genes result in loss of enzyme activity. A few studies evaluated the response to treatment and the polymorphisms of GSTT1 and GSTM1. The aim of this work is to make the ...

GSTM1 and GSTT1 catalyze detoxification of reactive oxygen and products of lipid peroxidation 14. Epidemiologic studies show that null genotypes for GSTM1 and GSTT1 are related to the increase of ...

Independent and combined effects of GSTM1, GSTT1 and GSTP1 IIe105Val polymorphisms with the risk of T2DM have been described in a number of original investigations, and the association of GSTs gene ...

A recent meta analysis of several literature sources reveals evidence linking polymorphisms of both the GSTM1 and GSTT1 enzymes, which are involved in kidney detoxification of carcinogens to the risk ...

This article deals with reviews on the effect of GSTT1 and GSTM1 polymorphism on lung cancer specifically from case-control studies of the Indian population. In the overall population, from the pooled ...

Our results suggested that the polymorphisms of GSTT1 and GSTM1 were associated with the methylation of arsenic, especially the levels of DMA and SMI.

For the analysis of GSTM1 or GSTT1, after discarding 4 articles [24-27] because they were not related to endometrial cancer and 1 article [5] due to insufficient genotype data, 6 case control studies ...

Abstract. Introduction: Colorectal cancer (CRC) remains a significant cause of mortality accounting for 10% of all deaths of malignancies in European Caucasians. Glutathione S-transferases (GSTs) ...

In conclusion, our study results suggest that GSTT1 null genotype is associated with the RCC susceptibility in Caucasians and Asians, and the dual null genotype of GSTM1-GSTT1 is associated with RCC ...

Abstract. Introduction: Oxidative stress plays an important role in hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC). Glutathione S-transferases (GSTs) prevent oxidative stress ...