在伊拉克这个膀胱癌负担日益加重的地区，科学家们将目光投向了人体重要的解毒卫士——谷胱甘肽S-转移酶家族 (GSTs)。这项精心设计的病例对照研究犹如一场分子侦探行动，采用四引物ARMS-PCR技术，在238名膀胱癌患者和310名健康人中追踪GSTM1、GSTT1和GSTP1基因的蛛丝马迹。 结果令人瞩目：携带GSTM1 ...

We carry out a study to analyze the relation between polymorphisms of GSTT1, GSTM1 and the capacity of arsenic methylation in a human population exposed to arsenic in drinking water. 230 randomly ...

本文通过荟萃分析证实，谷胱甘肽S-转移酶（GST）基因家族中GSTM1和GSTT1的无效多态性（null polymorphism）显著增加南亚人群口腔黏膜下纤维化（OSMF）的患病风险（ORGSTM1-null=1.46, ORGSTT1-null=1.97），且槟榔（areca nut）高暴露会放大该遗传风险。研究揭示GST酶活性缺失导致解毒功能受损，加剧氧化应激（ROS ...

Susceptibility to lung cancer has been shown to be modulated by inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which are ...

Kazem Zendehdel, Shahram Bahmanyar, Shane McCarthy, Olof Nyren, Bjorn Andersson, Weimin Ye, Genetic Polymorphisms of Glutathione S-Transferase Genes GSTP1, GSTM1, and GSTT1 and Risk of Esophageal and ...

Polymorphisms of 5 genes involved in drug metabolism (glutathione S-transferase (GST) P1 (IIe 105 Val), GSTT1 deletion, and GSTM1 deletion, methylenetetrahydrofolate reductase (MTHFR) (Ala 677 Val), ...

There was a statistically significant association of the GSTT1+ allele with low-risk mammographic findings (category BIRADS 1; p<0,05). Conclusions: The genotypic and allelic frequencies of the GSTT1 ...

Genotypes of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) were investigated on extracted genomic DNA of 37 exposed workers using the polymerase chain reaction based method. In exposed group ...

The glutathione S-transferase Gstt1 drives survival and dissemination in metastases. Nature Cell Biology, 2024; DOI: 10.1038/s41556-024-01426-7 ...