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易基因:ACE等揭示产前不良环境暴露通过DNA羟甲基化变化介导子代 ...
膜片钳技术显示,在1-NP暴露的断奶幼崽内侧前额叶皮层中的抑制性突触传递减少。免疫荧光显示,产前1-NP暴露减少了胎儿和断奶幼崽前额叶中谷氨酸脱羧酶67(GAD67)阳性的中间神经元数量。此外,产前1-NP暴露导致GAD67阳性中间神经元迁移延迟,并下调胎儿前脑 ...
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