Investigators at St. John’s University have published preclinical data regarding their endothelin-1 receptor (ETRA) antagonist HJP-272 for the potential treatment of cancer.

Abstract The consequences of endothelin receptor activation were examined in atrial tumor myocytes derived from transgenic mice (AT-1 cells). Endothelin-1 (endothelin) stimulates phosphoinositide hyd ...

The updated recommendations now include TRYVIO™ (aprocitentan) – the first and only hypertension treatment targeting the ...

Background—Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are ...

Background Giant-cell arteritis (GCA) is an inflammatory disease of large/medium-sized arteries, frequently involving the temporal arteries (TA). Inflammation-induced vascular remodelling leads to ...

In preclinical studies, endothelin receptor A (ETA) antagonists (ETAi) attenuated the progression of heart failure (HF). However, clinical HF trials failed to demonstrate beneficial effects of ETAi ...

A novel fluorescent photoprobe for the imaging of endothelin A receptors (ETAR) was developed. Based on the nonpeptidyl, high-affinity, and selective ETAR antagonist ...

Swiss pharma company Idorsia announced that its novel dual endothelin receptor antagonist (ERA), Tryvio (aprocitentan), has ...

诺华创新产品诺锐达®（盐酸阿曲生坦片）获得国家药品监督管理局批准，用于降低有疾病快速进展风险的原发性免疫球蛋白A肾病（ IGA肾病 ）成人患者的蛋白尿。一般来说，这类患者的尿蛋白肌酐比值（UPCR）≥ ...

高血压，这个“沉默的杀手”总是悄然而至，影响 平台声明：该文观点仅代表作者本人，搜狐号系信息发布平台，搜狐仅提供信息存储空间服务。

An intravitreal implant shows promise in enhancing visual function and retinal structure in diabetic retinopathy patients, ...

Deepak L. Bhatt, MD, MPH, MBA, of Mount Sinai Fuster Heart Hospital, spoke at the recent ASPC 2025 Congress on CVD Prevention ...