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Using karyotyping (examining her chromosomes), they found several rare genetic variants, including some on DSCAML1— a gene associated with aging brain health, aging and cancer, heart disease ...
Using karyotyping (examining her chromosomes), they found several rare genetic variants, including some on DSCAML1— a gene associated with aging brain health, aging and cancer, heart disease ...
Using karyotyping (examining her chromosomes), they found several rare genetic variants, including some on DSCAML1— a gene associated with aging brain health, aging and cancer, heart disease, and ...
These were involved in extracellular matrix integrity (CHD23, CLDN14, SPTBN1), neuronal differentiation (DSCAML1), cholesterol transport (GRAMD1B), transcriptional regulation (JARID2, LINC02111, ...
During the study, zebrafish with a DSCAML1 deficiency were found to have unbalanced reactions when introduced to stress. In fact, their cortisol levels were two to three times higher than in the ...
In zebrafish with the DSCAML1 deficiency, the response to that stress was out of balance. "Maladaptive stress responses can cause stress-associated disorders such as anxiety and depression," Pan said.
Deficiencies in DSCAML1 disrupt normal brain development and increase baseline levels of cortisol, making the hormone less able to function correctly during periods of stress. The findings shed new ...
Scientists focused on the molecule DSCAML1 because genetic changes in its human equivalent are seen in patients suffering from a wide range of mental health disorders, including intellectual ...
By contrast, no obvious assembly pattern is observed at the adhesion interfaces mediated by mouse DSCAML1 or Drosophila DSCAMs, suggesting the different structural roles and mechanisms of DSCAMs in ...
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