Basel researchers merge MHAT chemistry with enzymes, opening new pathways for greener pharmaceutical synthesis.

A collaborative research team has successfully developed designer enzymes that exhibit both intrinsic and extrinsic functions ...

CRISPR-associated transposases (CAST) revolutionize enzyme engineering, enabling precise modifications for improved ...

We employ both protein engineering and directed evolution methods in order to develop biocatalysts with tailored properties such high stereoselectivity, improved activity and enhanced stability. These ...

Using chiral biimidazoline ligands, diverse β-arylethylamines can be accessed with high stereoselectivity and reactivity.

In this review, we summarize the use of Diels–Alder reaction in the synthesis of arylene-based polymers, including polyphenylenes and ladder polymers, as well as graphene nanoribbons. These ...

Earlier studies with alcohols as nucleophiles, which are relatively reactive, indicated that a single halogen atom on an acetal can control stereoselectivity, although stereoselectivity was only ...

Macrocycles typically hinder the reactivity of adjacent functional groups in mechanically interlocked molecules due to steric shielding. Herein, we report a [2]rotaxane in which a bulky macrocycle in ...