PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

In a June 12 conference at UW-Madison, researchers gathered from across the U.S. and abroad to discuss the latest progress on TDP-43 biomarkers. In all, 74 people attended in person, and 727 virtually ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

An interactive timeline of the evolution of Alzheimer's Disease research.

Wei S, Yang W, Wang E, Wang S, Li Y. A 3D decoupling Alzheimer's disease prediction network based on structural MRI. Health Inf Sci Syst. 2025 Dec;13 (1):17. Epub 2025 Jan 17 PubMed.

Markers in the cerebrospinal fluid can help clinicians identify who has the amyloid and tangle pathologies of Alzheimer’s disease. However, no CSF marker has been found to track well with cognitive ...

Over the last 40 years, age-adjusted dementia prevalence in the U.S. has dropped by two-thirds. This predicts a 25 percent rise in total dementia cases by 2050, due to population aging. The findings ...

Overview Name: Nasal Insulin Synonyms: Detemir, Levemir, Humulin, Novolin, glulisine Therapy Type: Small Molecule (timeline), OtherTarget Type: Amyloid-Related (timeline), Other (timeline) Condition ...

Other news from AAIC? Long-term lecanemab dosing in open-label extensions now goes out to three years, and continues to support the idea that the antibody slows disease progression. On cognitive ...

“It was surprising to see C1q have such a profound effect on neuronal function,” Scott-Hewitt told Alzforum. She believes C1q may regulate translation in neurons of younger mice, but with age, these ...

EARLY ONSET FAMILIAL We have developed this special section of the Alzforum website to provide a resource for all who share an intense interest in familial early-onset AD (eFAD). We have created this ...

Several people who received Aβ-contaminated growth hormone in childhood developed dementia in midlife. Four of them had biomarker or pathological evidence of Alzheimer’s disease. This is the first ...