PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

Research News Parkinsonian disorders are difficult to diagnose. Clinical symptoms often overlap ...

Postdoctoral Position- Neurobiology of Parkinson’s Disease JOB 2025-07-09 Employer Université Laval Contact [email protected] Description The team specializes in the study of ...

To satisfy the incessant energy demands of their thousands of synapses, neurons have to have enormous supplies of ATP at the ready. Where does this seemingly bottomless well of energy come from? It’s ...

Thanks to cryo-electron microscopy, scientists have solved the structure of amyloid and tau fibrils—the hallmark protein pathologies of Alzheimer’s disease, and at the atomic level. As for Aβ42, they ...

While biomarkers have transformed Alzheimer’s research, much work remains to be done to develop these important tools for other neurodegenerative diseases, not to mention for the concurrent ...

Steps Forward: Immunoassays for cryptic HDGFL2 flag TDP-43 proteinopathy in diverse disorders. Companies have moved a PET ligand into Phase 1 trials.

NULISA assays measure AD biomarkers in blood as accurately as do gold-standard assays. A panel of 123 CNS proteins could aid differential diagnosis. It may also sharpen prognosis and profile a ...

CagA disrupts bacterial biofilms. It also prevents Aβ and α-synuclein from forming fibrils. Scientists will test CagA in AD and PD mouse models to assess its therapeutic potential. Scientists estimate ...

GNPC has assembled proteomic data on 40,000 blood and CSF samples from cohorts of neurodegenerative disease. The dataset will be released for public use July 15. GNPC scientists are adding more ...

Up-and-coming Alzheimer’s blood tests may soon be used for people with Down’s syndrome. In a longitudinal biomarker study of adults with three copies of ...