This useful study employs optogenetics, genetically-encoded dopamine and serotonin sensors, and patch-clamp electrophysiology to investigate modulations of neurotransmitter release between striatal ...

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Dysregulated myelopoiesis is identified as a driver of nutritionally acquired immunodeficiency that persists after refeeding and nutritional recovery, indicating exposure to food scarcity may be an ...

EPHA4 pathway dysfunction causes axon pathfinding defects, resulting in impaired coordinated left-right locomotion by disrupting neural patterning and the function of central pattern generators, ...

A new study details an efficient and scalable method to generate human inner ear hair-like cells in the lab, potentially offering a new tool for hearing loss research.

New research finds old age likely impacts the habitual tool-use behaviours of some wild chimpanzees, and the extent to which different individuals are affected is highly variable.

Nature is marked not only by struggles for survival, but also by remarkable feats of cooperation. From microbes to insects to humans, organisms work together in a variety of ways to gather and share ...

This article presents valuable findings on how the timing of cooling affects the timing of autumn bud set in European beech saplings. The study leverages extensive experimental data and provides an ...

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

The authors proposed two hypotheses: first, that methamphetamine induces neuroinflammation, and second, that it alters neuronal stem cell differentiation. These are valuable hypotheses, and the ...

Characterization of intracellular synapse heterogeneity aides to understand the intricate computational logic of neuronal circuits. Despite recent advances in connectomics, the spatial patterns of ...

Whole-mount 3D imaging at the cellular scale is a powerful tool for exploring complex processes during morphogenesis. In organoids, it allows examining tissue architecture, cell types, and morphology ...