New methods of analysis and novel markers are currently being identified to predict conditions with polygenic inheritance. These include polygenic risk scores (PRS), which are based on the ...

Special Article Published: 14 February 2013 How can polygenic inheritance be used in population screening for common diseases? Muin J. Khoury MD, PhD, A. Cecile J.W. Janssens PhD & David F ...

Similar to the way the caps on the ends of a shoelace prevent it from fraying, telomeres—regions of repetitive DNA sequences ...

The NHGRI's Clinical Genome Resource's (ClinGen) Complex Disease Working Group collaborated with the Polygenic Score Catalog, an open database of polygenic risk scores, to formulate the new framework.

Opinions differ as to the value of genetic information in the form of polygenic scores and the usefulness of polygenic score analysis as part of routine healthcare – clinical utility. Views on ...

According to the results, a higher polygenic risk for epilepsy was associated with an epilepsy diagnosis (OR = 1.39; 95% CI, 1.08-1.8), and relatives with a more severe phenotype had a mean ...

Children with higher polygenic scores showed accelerated BMI gain from age 2.5 years to adolescence in ALSPAC study.

Investigators recorded the association between low (T1), medium (T2) and high (T3) polygenic scores within each self-reported racial and ethnic group to seven documented survival outcomes: overall ...

Integration of polygenic scores (PGS) into clinical practice requires robust, validated mechanisms to generate these scores. A consistent message in our reports has been that to deliver PGS-based ...

Patients in the low polygenic risk group had a conversion rate of 3.2%, 6.2%, and 7.1% after 10, 15, and 20 years when randomized to early treatment.

The associations of CRC risk with FH, PVs in LS genes (MSH2, MLH1, MSH6, PMS2), and PGS were investigated in the UK Biobank (UKB) using population attributable risk percentage (PAR%) and Cox ...