本研究针对肾脏疾病诊断与预后监测中传统生物标志物的局限性，创新性地探讨了神经丝轻链蛋白 (Neurofilament Light Chain, NfL)在慢性肾脏病 (CKD)、急性肾损伤 (AKI)和糖尿病肾病中的临床应用价值。通过系统分析PubMed、Embase等六大数据库的现有证据，研究团队发现血清NfL水平与肾功能指标 (eGFR、血清肌酐 ...

Neurofilament light (NFL) is a powerful and sensitive biomarker for tracking neuronal health and disease progression.

Serum neurofilament light chain is a discriminative biomarker between frontotemporal lobar degeneration and primary psychiatric disorders. Journal of Neurology, 2019; DOI: 10.1007/s00415-019-09567-8 ...

CSF neurofilament may be one such surrogate marker," Avindra Nath, MD, professor of neurology at Johns Hopkins University, told Medscape Medical News.

Increased levels of neurofilament light in plasma samples correlated with a greater risk for ALS, according to findings from an analysis of plasma samples obtained within 5 years of an ALS ...

In persons with SOD1 ALS, tofersen reduced concentrations of SOD1 in CSF and of neurofilament light chains in plasma over 28 weeks but did not improve clinical end points and was associated with ...

The blood-based measure of neurofilament light chain was associated with the presence of neuronal injury in those with peripheral neuropathy, according to a systematic review and meta-analysis in ...

recognises non phosphorylated 200 kD neurofilament heavy expressed in neuronal cell bodies, dendrites and some thick axons in the central and peripheral nervous system; not thin axons or ...

Blood-based measurement of neurofilament light chain (NfL) provides compelling evidence to support an accelerated drug approval by the FDA. The decision has positive implications for NfL blood ...

Specificity phosphorylated neurofilament H and, to a lesser extent, neurofilament M is detected in most mammalian species, in thick and thin axons but not cell bodies ...