Microsomal prostaglandin E synthase-1 (mPGES-1) plays a pivotal role in the biosynthesis of prostaglandin E₂ (PGE₂), a key mediator of inflammation, pain and fever. Unlike conventional non ...

The purpose of our paper is to develop and validate a fluorescence-based mouse liver microsomal (MLM) assay in screening pharmaceutical reactive metabolites (RMs) using a glutathione (GSH)-conjugated ...

Pirola and Lieber (2) reported that activation of the microsomal ethanol oxidizing system (MEOS) in hepatocytes of alcoholics may consume one third of the caloric content of ethanol and impair ATP ...

Selectivity for closely related isoforms of protein kinases is a major challenge in the design of drugs and chemical probes. Covalent targeting of unique cysteines is a potential strategy to achieve ...