Antibodies are proteins that circulate in the blood and protect against foreign antigenic substances such as bacteria, ...

Hepatitis C vaccine development can be accelerated now that cryo-electron microscopy has revealed new details about the virus ...

One of the main challenges of developing an HIV-1 vaccine lies in eliciting immune responses that can overcome the antigenic variability exhibited by HIV. Most HIV-1 vaccine development has ...

Amplicon library for bidirectional (2×250 bp) sequencing on Illumina MiSeq platform was constructed using universal primers 515f, 5′-GTGCCAGCMGCCGCGGTAA-3′ and 806r, 5′-GGACTACHVGGGTWTCTAAT-3′ ...

This important study extends existing sequentially Markovian coalescent approaches to include the combined use of SNPs and hypervariable loci such as epimutations. This is an intriguing addition to ...

Agarose gel electrophoresis and NanoDrop One (Thermo Fisher Scientific) were performed to examine the quality of DNA samples. Afterwards, DNA extracts were used to amplify V3–V4 hypervariable regions ...

The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.

图三：HCV E1/E2复合物中跨膜结构域的位置和结构。 其次，结构中首次解析了E2蛋白N末端的区域，包括序列最多样化的hypervariable region 1(HVR1)以及序列保守但结构非常不稳定的antigenic site 412(AS412)。这些区域被认为对HCV的免疫逃逸至关重要，但其具体作用机制和结构 ...

CDR为全身变异性最大的地方，以捕捉不同抗原，所以也常被称为高变区（hypervariable regions）。 抗体上半部分（Fab区）。红色部分标注的是重链上的互补决定区。（PDB1IGT） 抗体示意图。蓝色与浅蓝色部分均为可变域（variable domains），浅蓝色的为CDRs（属于可变域 ...

2021). The complete sequencing protocol can be found here. Briefly, the hypervariable region of the 16S rRNA gene was synthetically reconstructed from a series of standard Illumina PE150 reads, ...