MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

Mechanistically, NF-κB signaling-induced-Vangl2 recruits E3 ubiquitin ligase PDLIM2 to catalyze K63-linked ubiquitination on p65, which serves as a recognition signal for cargo receptor NDP52-mediated ...

As autophagy generally plays a protective role in cancer therapy, and both PFKFB3 deprivation and membrane transporter/ion channel inhibitors attenuated the autophagic flux induced by DDP, thus, the ...

Autophagy is a natural process by which a cell breaks down old, damaged, unnecessary, or dysfunctional components within a cell and then repurposes those components for fuel and to build or maintain ...

Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the ...

研究首次提出RNA结合蛋白AUF1通过抑制溶酶体组织蛋白酶D（CTSD）的表达来抑制CagA的自噬降解，并促进积累在细胞内的CagA进入外泌体进而引发胞外炎症的新机制，表明AUF1是CagA的一种新的宿主正向调控因子。

研究首次提出RNA结合蛋白AUF1通过抑制溶酶体组织蛋白酶D（CTSD）的表达来抑制CagA的自噬降解，并促进积累在细胞内的CagA进入外泌体进而引发胞外炎症的新机制，表明AUF1是CagA的一种新的宿主正向调控因子。