为了探索唑喹达下调PD-L1的分子机制，研究人员研究了唑喹达对PD-L1蛋白稳定性和mRNA水平的影响。研究人员发现唑喹达显著缩短了PD-L1蛋白的半衰期，而对mRNA水平没有影响。此外，与蛋白酶体抑制剂MG132相比，溶酶体抑制剂NH4Cl抑制了唑 ...

本文发表后，一位热心的读者向编辑指出，第3763页图1D中显示的某些细胞凋亡测定数据，与另一篇由不同研究机构的不同作者以不同形式提交发表的文章（图3A）中的数据惊人地相似。鉴于上述有争议的数据在提交给《 Molecular Medicine ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

Although the Cvt pathway is the only known biosynthetic use of autophagy, selectivity represents an important aspect of many autophagic processes. For example, specific organelle degradation has ...

研究首次提出RNA结合蛋白AUF1通过抑制溶酶体组织蛋白酶D（CTSD）的表达来抑制CagA的自噬降解，并促进积累在细胞内的CagA进入外泌体进而引发胞外炎症的新机制，表明AUF1是CagA的一种新的宿主正向调控因子。

Autophagy, which literally means "self-eating," is a cellular cleaning-out process that maintains our bodies in good order, ...

Autophagy implicates in a variety of biological processes and disease developments. We developed Bioluminescence Resonance Energy Transfer (BRET)-based high throughput chemical screening to regulate ...

RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...

1.Watanabe T, Seki T, Fukano T, Sakaue-Sawano A, Karasawa S, Kubota M, Kurokawa H, Inoue K, Akatsuka J, Miyawaki A.: "Genetic visualization of protein interactions ...

Bile acids are byproducts of cholesterol metabolism in the liver and constitute the primary components of bile. Disruption of ...