Both NADP+ and NADPH levels were decreased in dox-treated cells (Fig. EV6A,B). To verify that NADPH production is indeed decreased in NRF2 knockdown cells, we performed a stable isotope tracing ...

已知PTEN的缺失通过稳定G6PD来调节PPP和NADPH的产生， 医学高通量靶向代谢组学 显示，RIOK1过表达上调PPP相关代谢物，降低NADP+/NADPH比值（图3a-d）。