Participation of endothelin in salt-sensitive essential hypertension could be mediated by a deficit in its natriuretic actions, or by an exaggerated contribution to the control of vasoconstriction ...

Endothelin-1 is a small vasoconstrictor peptide that was first identified in 1988. Here we review the evidence implicating ET-1 in tumorigenesis. In particular, we concentrate on the role of ET-1 ...

The updated recommendations now include TRYVIO™ (aprocitentan) – the first and only hypertension treatment targeting the ...

There is increasing evidence that endothelin-1 has a pathogenic role in pulmonary arterial hypertension 10 and that blockade of endothelin receptors may be beneficial. 11 Endothelin-1 is a potent ...

The dual endothelin-receptor antagonist macitentan was developed by modifying the structure of bosentan to increase efficacy and safety. 14 Macitentan is characterized by sustained receptor ...

Investigators at St. John’s University have published preclinical data regarding their endothelin-1 receptor (ETRA) antagonist HJP-272 for the potential treatment of cancer.

Are selective endothelin-receptor antagonists really an important new advance for treating patients with treatment-resistant hypertension? The evidence from a recent study leaves us with some ...

CHICAGO — Aprocitentan, a dual endothelin antagonist, was superior to placebo for BP lowering and was well tolerated in patients with resistant hypertension, according to results of the ...

An intravitreal implant shows promise in enhancing visual function and retinal structure in diabetic retinopathy patients, ...

Here, we describe our findings how vimentin 3 is part of the signaling pathways from Endothelin-1 (ET-1) and the Endothelin-A-Receptor (ETAR) and how it correlates with aggressive tumor behavior in a ...

The approved ANDA is therapeutically equivalent to the reference listed drug product (RLD), Opsumit tablets, 10 mg, of ...

Focal Segmental Glomerulosclerosis (FSGS) is a rare kidney disorder characterized by scarring (sclerosis) in the glomeruli, leading to proteinuria, progressive kidney damage, and potential kidney ...