The rules that govern memory T cell differentiation are not well understood. This study shows that after antigenic stimulation naïve CD8+ T cells become committed to dividing at least seven times ...

One potential predictor is CD8 cell count. These immune system cells have an important role in fighting untreated HIV infection. However, an overstimulation of CD8 response and an elevated cell count ...

CD3/CD8 densities have been most studied as prognostic biomarkers in CRC, and results across studies show consistent associations. 12 One well-established IHC-based method of CD3/CD8 TIL assessment is ...

Researchers have found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung-resident alveolar macrophages (AMs). This interaction ...

A new exploratory study will evaluate the safety of Anktiva in patients with long COVID, with secondary and exploratory ...

In terms of specific cancers, a low CD4/CD8 ratio (0.3 or less) was associated with an increased risk for non-Hodgkin lymphoma, Kaposi sarcoma, lung cancer, anal cancer and colorectal cancer, again ...

Davis was surprised to find that levels of CD8 cells were lower among people who had gotten vaccinated after recovering from COVID-19, compared to those who had been vaccinated and never infected.

The finding (“ Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity ”), published in Nature Communications, could eventually be used to develop new strategies to augment ...

The reduced CD8 + T cell responses to vaccination indicate that individuals who have had prior SARS-CoV-2 infections could be vulnerable to subsequent infections despite being vaccinated.

To investigate the intrinsic role of aging on CD8 + T cell function, Prof. XIAO Yichuan 's team from SINH and collaborators isolated CD8 + T cells from young and aged mice and then adoptively ...

Intrinsic IL-2 production by effector CD8 T cells affects IL-2 signaling and promotes fate decisions, stemness, and protection. Science Immunology, 2022; 7 (68) DOI: 10.1126/sciimmunol.abl6322 ...