资讯

MYC基因参与了细胞增殖、代谢、衰老、凋亡和血管生成等多个生物学过程的调控。c-MYC癌基因在70%肿瘤中的高表达与肿瘤发生发展、侵袭、耐药和不良预后密切相关,使其成为肿瘤治疗的重要靶点。由于c-MYC具有无序结构域并且缺乏小分子药物结合口袋,靶向c ...
Obesity elevates the risk of at least 13 major cancers, including those of the breast, colon and liver. It also impairs immune responses that target tumors and are stimulated by cancer immunotherapies ...
癌症,这个人类健康的头号大敌,其背后往往潜藏着一个“总司令”级别的驱动基因。在众多这样的基因中,MYC无疑是“众癌之王”——它像一个失控的引擎,在许多最具侵袭性、最难治疗的癌症中疯狂运转,驱动着肿瘤的生长和耐药 ...
cut&tag显示P3代c-MYC在SOX5/SOX6基因区域的结合减少。 机制上,钙离子上调钙调蛋白(CALM2),后者竞争性结合RNA稳定蛋白HuR,导致MYC mRNA降解。
胃淋巴瘤转移至腹腔且细胞学检出淋巴瘤细胞,表明疾病已进入晚期(IV期),属系统性播散。其处理需结合病理亚型、累及范围及患者状态制定分层策略,核心依据包括NCCN淋巴瘤指南、Lugano分期系统及近年循证进展。
Scientists have developed a chemical method to reverse aging in human cells without the need for genetic modification.
Two kids were killed and two more are in critical condition after a barge struck their boat and sent them overboard during a ...
Former Trump Department of Homeland Security official Ken Cuccinelli discusses Trump administration deportation policies and former VOA national correspondent Steve Herman discusses the impact of ...