2018 Meetings Abstracts: Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic January 8–11, 2018; San Diego, CA Proceedings: AACR Annual ...

Loss of the NFκB pathway inhibitor TRAF3 increased MHC-I expression, improving T cell–mediated cancer cell killing and tumor responsiveness to immune checkpoint blockade, an effect that could be ...

Cancer cells reprogrammed into the myeloid lineage adopt an antigen-presenting cell phenotype and function, present endogenous tumor antigens, and stimulate robust antitumor immunity in hematologic ...

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This study uncovers a role for OSMR in promoting ovarian cancer cell proliferation and metastasis by activating STAT3 signaling and demonstrates the preclinical efficacy of antibody-based OSMR ...

Stromal targeting with PDGFRα/β dual blockade reverses the immunosuppressive microenvironment and enhances the efficacy of immune checkpoint inhibitors in fibrotic cancer.

This work defines how hnRNPK links TNFα signaling and Hippo pathway transcription coactivator YAP in hepatic progenitor cells during primary liver tumorigenesis.

Colorectal cancers express abundant viral-like repeat elements that can be targeted by nucleoside reverse transcriptase inhibitors in preclinical models, which was further translated into a phase II ...

In the U.S., incidence rates of some cancers have increased in 15- to 49-year-olds with concomitant increases in older age groups, suggesting that changes in risk factor prevalence and/or improvements ...

The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. The cGAS–STING pathway was ...