Letter Published: 15 October 1960 Inhibition of Exogenous and Endogenous Pyrogens by Lysozyme P. CASELLI & C. CALLERIO Nature 188, 238 (1960) Cite this article ...

Cytokines are pleiotropic molecules mediating several pathologic processes. Long before the discovery of cytokines as immune system growth factors or as bone marrow stimulants, investigators learned a ...

When the infection subsides, pyrogens decrease and the hypothalamus resets the temperature. You sweat, your blood vessels dilate, and you cool off. You’re feeling better.

When the infection subsides, pyrogens decrease and the hypothalamus resets the temperature. You sweat, your blood vessels dilate, and you cool off. You’re feeling better.

The immune system responds by releasing molecules called pyrogens, which induce fever. They signal the brain’s hypothalamus to raise the body’s set point temperature—like adjusting a thermostat.

When the infection subsides, pyrogens decrease and the hypothalamus resets the temperature. You sweat, your blood vessels dilate, and you cool off. You’re feeling better.