对于膜通透性肽：alamethicin和melittin，作者通过分子模拟展示了如何区分平衡和瞬时泄漏过程，并预测了详细的孔结构和穿透机制。 这项题为“Melittin can permeabilize membranes via large transient pores”（Melittin通过大型瞬时孔道使膜通透）的研究已发表在Nature Communications（自然·通讯）上。

癌症治疗面临三大挑战：传统化疗药物如多柔比星（DOX）和SN-38存在水溶性差、毒副作用强的问题；膜溶解肽如蜂毒肽（melittin）虽能破坏肿瘤细胞膜，但缺乏选择性；不同机制药物的协同给药面临药代动力学差异的难题。

The melittin-binding capacity of PDA nanoparticles is higher than 1 mmol g −1. This capacity is greater than that of previously reported protein-adsorbing films 25, ...

Melittin is a widely studied membrane active peptide, or MAP, that interacts with cell membranes. Researchers are interested in melittin and other MAPs from animal venom because of their potential ...

As melittin sticks to the GUV, its surface area increases by up to 4.5 percent, as measured by the expanding column at left. When melittin loads reach a critical threshold, ...

Melittin forms pores in the cancer cell membranes which could potentially help the entry of other treatments into the cancer cell, to help destroy the cancer, according to the press release.

Melittin effectively reduces inflammation by inhibiting the critical DNA binding activity of NF-kB (Nuclear Factor kappa B), which directly controls a number of genes involved in immune reactions.

Central to this study is melittin, the active component of honeybee venom, which constitutes about half of the venom’s dry weight. Melittin is a 26-amino-acid peptide with a positive charge.

Melittin in honeybee venom also had another remarkable effect; within 20 minutes, melittin was able to substantially reduce the chemical messages of cancer cells that are essential to cancer cell ...

Bee venom contains several ingredients with pharmaceutical potential. These include melittin, a peptide found in the European honey bee’s venom that has attracted scientists’ attention since the 1950s ...

Melittin, meanwhile, was found to “completely destroy cancer cell membranes within 60 minutes,” according to Duffy. "We found both honeybee venom and melittin significantly, ...