Protective alleles confer protection against disease by disrupting protein function, typically via loss-of-function (LoF) effects. Protective alleles have been identified for a range of complex ...

Gene vs allele Genes are chunks of DNA that contribute to particular traits or functions by coding for proteins that influence physiology. Alleles are different versions of a gene, which vary ...

Research Article Published: 24 January 2002 How many alleles per locus should be used to estimate genetic distances? S T Kalinowski Heredity 88, 62–65 (2002) Cite this article ...

Major-histocompatibility-complex alleles determine the tissue compatibility that is necessary for the acceptance of transplanted tissues. 1 Graft survival after kidney and heart transplantation is ...

We all have two alleles, or versions, of each gene. Being homozygous for a particular gene means you inherited two identical versions. Here's how that can affect your traits and health.

Researchers developed a high-accuracy method to infer whether genetic variants come from the mother or father without needing ...

We prove that the frequencies of the oldest, second-oldest, third-oldest, ⋯ alleles in the stationary infinitely-many-neutral-alleles diffusion model are distributed as X1, (1-X1)X2, (1-X1) (1-X2)X3,⋯ ...

Since these alleles have been around for more than 5000 years, they may in fact have some evolutionary advantage. “Common [gene] variants have subtle roles across the genome, affecting multiple ...

There are two basic alleles, short and long (the long gene has 14 repeats of the same sequence while the short gene is 12), so three genotypes (as we get one from mom and one from dad) are: short ...

With a small effective population size, random genetic drift is more important than selection in determining the fate of new alleles. Small populations therefore accumulate deleterious mutations. Left ...

Heterozygous example In a heterozygous genotype, the two different alleles interact with each other. This determines how their traits are expressed. Commonly, this interaction is based on dominance.