The viability of parasitic protozoa is severely diminished by imparing thymidylate (dTMP) biosynthesis. The absence of enzymatic activities which are specifically involved in the formation of dTMP ...

The predictive values of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) gene expressions were retrospectively evaluated in patients with gastric cancer treated by a regimen ...

High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with ...

Purpose: To investigate the role of thymidylate synthase (TS), p53, and epidermal growth factor receptor (EGF-R) expressions in hepatic tumors in predicting overall survival (OS), progression-free ...

Abstract Purpose: The aim of this study was to investigate the utility of quantitating thymidylate synthase (TS) in the primary tumor as a surrogate for metastatic disease sites to predict the ...

Thymidylate synthase (TS) is a substance that the body produces naturally. Cancer cells need TS to be able to copy their DNA before they divide into 2 new cells. Researchers think that treatment for ...

The presence of dUMP in DNA from cells treated with methotrexate is a result of the great increase in intracellular concentration of dUTP and the fall in dTTP that accompany inhibition of thymidylate ...