Thalidomide does not appear to treat the disease itself, but it may make it much more bearable. Gwartney and Chambers enrolled in the Johns Hopkins study hoping for some sort of relief.

Thalidomide is also used off-label for treating HIV-related mouth and throat ulcers and is thought to be effective in Kaposi’s sarcoma, weight loss and body-wasting associated with HIV.

Importantly, thalidomide stimulates cytotoxic-T-cell proliferation and induces secretion of interferon-γ and IL-2. 30 Specifically, thalidomide and IMiDs induce activation of the CD28 co ...

Thalidomide appears to inhibit the action of basic fibroblast growth factors, endothelial cell proliferation, circulating endothelial cells, and expression of tumor necrosis factor α, while ...

Median tolerated dose of thalidomide was 200 mg a day. In conclusion, thalidomide as maintenance therapy is feasible and may improve outcome after single autologous stem cell transplant.

1998 — Thalidomide is approved by the FDA for treating a complication of leprosy. 2006 — Thalidomide is approved for treating multiple myeloma, a bone marrow cancer.

The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-20911-2 ...

Thalidomide was once prescribed to pregnant women, beginning in the late 1950s, before doctors realized it caused severe birth defects — babies stillborn, or born without limbs, or with ...

Thalidomide pills were prescribed in the late 1950s for morning sickness and as a sedative. New Jersey-based Celgene Corp. won Food and Drug Agency approval to use the drug for a painful side ...

Thalidomide was also used in the late 1960s and 1970s to heal ulcers in patients with leprosy. It is now approved in numerous countries around the world to treat types of leprosy.

Thalidomide, a drug whose name for decades has been synonymous with nightmarish birth defects and death, was approved Thursday to treat a painful symptom of leprosy. In licensing the notorious ...

Morton Mintz, who has died aged 103, was the investigative journalist who broke the story about the birth defects associated ...