靶向蛋白降解技术发展至今，已经有 30 多个管线正在肿瘤临床试验中。除肿瘤外，许多靶向蛋白降解药物在治疗神经退行性疾病、自身免疫性疾病、炎症性疾病以及病毒细菌感染方面也显示出巨大前景。

Chronic graft-versus-host disease (GVHD) refractory to standard immunosuppressive therapy remains a major cause of morbidity and mortality after allogeneic bone marrow transplantation (BMT ...

针对不可切除肝细胞癌 (HCC)患者经导管动脉化疗栓塞 (TACE)单药疗效不佳的临床难题，复旦大学附属中山医院团队开展了一项多中心随机对照试验，证实TACE联合沙利度胺 (Thalidomide)、卡莫氟 (Carmofur)和复方斑蝥胶囊 (CMC)组成的TCC鸡尾酒疗法可显著提高1-3年总生存率 (83.2% vs 54.3%)和无进展生存率 (66.3% vs 34 ...

Thalidomide Thalidomide in 100 mg capsules was provided by Grünenthal (Aachen, Germany) on a compassionate-use basis. The drug was administered once a day in the evening, starting with 100 mg/day.

Treatment consisted of capecitabine at 1,000 mg/m 2 po BID for 14 days every 3 weeks and thalidomide starting at 200 mg po daily continuously. Thalidomide was escalated individually to 600 mg po daily ...

Thalidomide hailed as a 'wonder drug' for morning sickness after it was created by German pharmaceutical giant Gruenenthal Group in the 1950s. But it was blamed for the deaths of 100,000 babies ...

Thalidomide does not appear to treat the disease itself, but it may make it much more bearable. Gwartney and Chambers enrolled in the Johns Hopkins study hoping for some sort of relief.

Thalidomide is the infamous drug at the heart of one of the world's worst drug safety catastrophes in modern medicine. And yet, more recent research is finding that thalidomide is still worth using, ...

New Thalidomide-Like Therapy Hijacks Cells’ Trash-Disposal System Cancer treatment using the notorious drug may hold promise for other diseases like Alzheimer’s ...

Thalidomide was once prescribed to pregnant women, beginning in the late 1950s, before doctors realized it caused severe birth defects — babies stillborn, or born without limbs, or with ...

Thalidomide - A Second Chance? - transcript. Horizon tells the tale of thalidomide and how this drug that was once so infamous may now be giving hope to people who otherwise face death.

Thalidomide maker issues apology LONDON, Sept. 1 (UPI) -- A British charity representing families hurt by the drug thalidomide in the 1950s and 1960s said the company apology was not enough.