The box H/ACA pseudouridine synthase complex guides modification of small nucleolar and Cajal body ribonucleoproteins (sno/scaRNAs), which are essential for maturation of the ribosome and ...

This further allowed the group to identify five conserved pseudouridine sites on the 3’ end of SARS-CoV-2 sub-genomic RNAs, which could potentially be beneficial to the virus in immune evasion.

Pseudouridine (Ψ) is widely distributed in mRNA and various non-coding RNAs in yeast and mammals, and the specificity of its distribution has been determined. However, knowledge about Ψs in the RNAs ...

PseudoUridine (Ψ) is a post-transcriptional RNA modification that alters RNA-RNA and RNA-protein interactions and affects gene expression. PseudoUridine modification is also named "fifth base" since ...

Pseudouridine is a modification of cellular RNAs that is widespread in nature, particularly in vertebrate RNA. Back in 2005, a groundbreaking study showed that pseudouridine in synthetic mRNA ...

Colorectal cancer (CRC) is a globally prevalent malignancy with high morbidity and mortality rates, closely linked to aberrant epigenetic modifications. Among these, pseudouridine (Ψ), one of ...

The global Pseudouridine market size was significantly robust in 2021 and is expected to register a steady revenue CAGR over the forecast period (2023-2033). Revenue growth of the global Pseudouridine ...

“At a biochemical level, pseudouridine affects some of the fundamental properties of RNA,” Gilbert said. “In particular, changing a uridine to a pseudouridine stabilizes RNA duplexes — base pairing ...

EnginZyme reports that it has patented a process to synthesize pseudouridine, a key ingredient in mRNA COVID-19 vaccines. The company and its CDMO partner, Ajinomoto Bio-Pharma Services, say they ...